Technology Process of 8-amino-2,6-dimethoxy-5-(3-methoxyphenyl)-4-methyl-quinoline
There total 5 articles about 8-amino-2,6-dimethoxy-5-(3-methoxyphenyl)-4-methyl-quinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
10% palladium on activated carbon; hydrogen;
In
ethyl acetate;
at 20 ℃;
under 2585.81 Torr;
DOI:10.1021/jm100911f
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux
2: 10% palladium on activated carbon; hydrogen / ethyl acetate / 20 °C / 2585.81 Torr
With
10% palladium on activated carbon; tetrabutylammomium bromide; hydrogen; palladium diacetate; sodium carbonate; triphenylphosphine;
In
1,2-dimethoxyethane; water; ethyl acetate;
1: Suzuki coupling;
DOI:10.1021/jm100911f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol / 43 h / Reflux; Inert atmosphere
2.1: sulfuryl dichloride / acetic acid / 0.5 h / 60 °C / Inert atmosphere
3.1: phosphorus pentoxide / triethyl phosphate / 1 h / 20 °C / Inert atmosphere
3.2: 0.25 h / 35 °C / Reflux; Inert atmosphere
4.1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux
5.1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 20 °C / 2585.81 Torr
With
sulfuryl dichloride; phosphorus pentoxide; 10% palladium on activated carbon; tetrabutylammomium bromide; hydrogen; palladium diacetate; sodium carbonate; triphenylphosphine;
In
methanol; 1,2-dimethoxyethane; triethyl phosphate; water; acetic acid; ethyl acetate;
4.1: Suzuki coupling;
DOI:10.1021/jm100911f
