dimethyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

Base Information

• Chemical Name: dimethyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate
• CAS No.: 1367824-40-5
• Molecular Formula: C₁₆H₂₆NO₅PS
• Molecular Weight: 375.426
• Mol file: 1367824-40-5.mol

Synonyms:dimethyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

Chemical Property of dimethyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

There total 5 articles about dimethyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

diphenyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate (1367824-36-9) + sodium methylate (124-41-4) → dimethyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate (1367824-40-5)

Guidance literature:

With methanol; In 1,4-dioxane; at 20 ℃;

Reference yield:

3-phenylsulfanyl-propionaldehyde (27098-65-3) → dimethyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate (1367824-40-5)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 1 h / 80 °C

2: hydrogen bromide; acetic acid / water

3: triethylamine / dichloromethane / 0 - 20 °C

4: methanol / 1,4-dioxane / 20 °C

With methanol; hydrogen bromide; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; water;

Reference yield:

thiophenol (108-98-5) → dimethyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate (1367824-40-5)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: acetic acid / 1 h / 80 °C

3: hydrogen bromide; acetic acid / water

4: triethylamine / dichloromethane / 0 - 20 °C

5: methanol / 1,4-dioxane / 20 °C

With methanol; hydrogen bromide; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

[3-(phenylsulfanyl)-1-(RS)-(diphenoxyphosphoryl)propan-1-aminium] bromide

diphenyl [(RS)-1-(tert-butoxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

sodium methylate

3-phenylsulfanyl-propionaldehyde

Downstream raw materials:

[(RS)-1-amino-3-(phenylsulfanyl)propyl]phosphonic acid