(R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine

Base Information

Chemical Name:(R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine
CAS No.:1352743-21-5
Molecular Formula:C₂₀H₂₉NO₂Si
Molecular Weight:343.541
Hs Code.:

Synonyms:(R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine

Chemical Property:

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Technology Process of (R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine

There total 5 articles about (R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1352743-15-7
(R)-2-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-6-methylpyridin-4(1H)-one

: 74-88-4
methyl iodide

: 1352743-21-5
(R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-07-7
(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

: 1352743-21-5
(R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 16 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100681

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 1352743-21-5
(R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxy-6-methylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / tetrahydrofuran / 16 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

4: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 16 h / Reflux

5: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

With 1H-imidazole; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100681