(R)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

Chemical Name:(R)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:1352743-41-9
Molecular Formula:C₃₀H₃₆F₃NO₅Si
Molecular Weight:575.7
Hs Code.:

Synonyms:(R)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Chemical Property of (R)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Technology Process of (R)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 18 articles about (R)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1352743-35-1
(R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 1352743-41-9
(R)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-35-1
(R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol

: 20445-31-2,56135-03-6,81655-41-6,17257-71-5
MTPA

: 1352743-41-9
(R)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

: (S)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-07-7
(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

: 1352743-41-9
(R)-(6-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-4-methoxypyridin-2-yl)methyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 16 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

4: 2 h / 90 °C

5: potassium carbonate / methanol / 6 h / 20 °C

6: triethylamine; HATU / dichloromethane / 16 h / 20 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide; 4: Boekelheide rearrangement;
DOI:10.1002/ejoc.201100681