tert-butyl 4-[3-[4-(piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[3-[4-(piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate
CAS No.:1240299-95-9
Molecular Formula:C₂₃H₃₇N₃O₃
Molecular Weight:403.565
Hs Code.:

Synonyms:tert-butyl 4-[3-[4-(piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-[3-[4-(piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

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Technology Process of tert-butyl 4-[3-[4-(piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-[3-[4-(piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1240299-95-9
tert-butyl 4-[3-[4-(piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 - 25 °C / Inert atmosphere

4.1: hydrogen / 5%-palladium/activated carbon / methanol / 16 h / 25 °C / 3750.38 Torr

With di-isopropyl azodicarboxylate; hydrogen; sodium carbonate; triphenylphosphine; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: C₃₁H₄₁N₃O₅

: 1240299-95-9
tert-butyl 4-[3-[4-(piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In methanol; at 25 ℃; for 16h; under 3750.38 Torr;

Reference yield:

: 132710-90-8
4-(3-hydroxy-propyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1240299-95-9
tert-butyl 4-[3-[4-(piperidin-4-yl)phenoxy]propyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 - 25 °C / Inert atmosphere

2: hydrogen / 5%-palladium/activated carbon / methanol / 16 h / 25 °C / 3750.38 Torr

With di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol;