N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide
CAS No.:1274817-12-7
Molecular Formula:C₁₉H₂₁N₃O₂
Molecular Weight:323.395
Hs Code.:

Synonyms:N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide

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Chemical Property of N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide

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Technology Process of N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide

There total 1 articles about N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4487-50-7
2-amino-4-nitropyridine

: 1274817-12-7
N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 30 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 100 °C

With pyridine; caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm101479y

Reference yield:

: 1237535-90-8
3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

: 1274817-12-7
N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide

: 1274817-11-6
N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride

Guidance literature:: 3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt; N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide; With pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether;

With hydrogenchloride; In diethyl ether; at 0 - 20 ℃; for 0.416667h;
DOI:10.1021/jm101479y