3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

Base Information

Chemical Name:3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt
CAS No.:1237535-90-8
Molecular Formula:C₁₁H₁₁F₃NO₂*Li
Molecular Weight:253.15
Hs Code.:

Synonyms:3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

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Chemical Property of 3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

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Technology Process of 3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

There total 3 articles about 3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1237535-89-5
1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine

: 1237535-90-8
3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

Guidance literature:: 1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

carbon dioxide; In tetrahydrofuran; hexane; at -78 ℃;

Reference yield:

: 1237535-89-5
1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine

: 1237535-90-8
3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

Guidance literature:: 1-[3-bromo-5-(trifluoromethyl)phenyl]-N,N-dimethylmethanamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

With carbon dioxide; In tetrahydrofuran; hexane;

Reference yield:

: 477535-41-4
3-bromo-5-(trifluoromethyl)benzaldehyde

: 1237535-90-8
3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran; dichloromethane / 0.25 h / 20 °C

1.2: 3 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 0.25 h / -78 °C

With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm101479y