N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride

Base Information

Chemical Name:N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride
CAS No.:1274817-11-6
Molecular Formula:C₃₀H₃₁F₃N₄O₃*ClH
Molecular Weight:589.057
Hs Code.:

N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride

Synonyms:N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride

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Chemical Property of N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride

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Technology Process of N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride

There total 14 articles about N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4487-50-7
2-amino-4-nitropyridine

: 1274817-11-6
N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 30 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 100 °C

3.1: pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / diethyl ether

3.2: 0.42 h / 0 - 20 °C

With pyridine; hydrogenchloride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm101479y

Reference yield:

: 1237535-90-8
3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt

: 1274817-12-7
N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide

: 1274817-11-6
N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride

Guidance literature:: 3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzoic acid lithium salt; N-(4-([(7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)pyridin-2-yl)cyclopropanecarboxamide; With pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether;

With hydrogenchloride; In diethyl ether; at 0 - 20 ℃; for 0.416667h;
DOI:10.1021/jm101479y

Reference yield:

: 477535-41-4
3-bromo-5-(trifluoromethyl)benzaldehyde

: 1274817-11-6
N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; dichloromethane / 0.25 h / 20 °C

1.2: 3 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 0.25 h / -78 °C

3.1: pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / diethyl ether

3.2: 0.42 h / 0 - 20 °C

With pyridine; hydrogenchloride; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm101479y