2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine

Base Information

Chemical Name:2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine
CAS No.:180153-43-9
Molecular Formula:C₁₂H₅Cl₂F₄NO
Molecular Weight:326.077
Hs Code.:

Synonyms:2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine

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Chemical Property of 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine

Chemical Property:

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Technology Process of 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine

There total 6 articles about 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 195304-19-9
2-chloro-5-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-4-fluoroaniline

: 180153-43-9
2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine

Guidance literature:: 2-chloro-5-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-4-fluoroaniline; With sulfuric acid; sodium nitrite;

With copper(II) sulfate;
DOI:10.2533/000942903777678650

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 180153-43-9
2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 81 percent / Pd(PPh₃)4; Na₂CO₃

2.1: 95 percent / HNO₃; H₂SO₄

3.1: 98 percent / H₂ / Pt/C / various solvent(s)

4.1: 86 percent / HF

5.1: NaNO₂; H₂SO₄

5.2: 74 percent / CuSO₄

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen fluoride; hydrogen; nitric acid; sodium carbonate; sodium nitrite; platinum on activated charcoal; In various solvent(s); 1.1: Suzuki coupling / 4.1: Bamberger rearrangement;
DOI:10.2533/000942903777678650

Reference yield:

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 180153-43-9
2-(4-chloro-2-fluoro-5-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 81 percent / Pd(PPh₃)4; Na₂CO₃

2.1: 95 percent / HNO₃; H₂SO₄

3.1: 98 percent / H₂ / Pt/C / various solvent(s)

4.1: 86 percent / HF

5.1: NaNO₂; H₂SO₄

5.2: 74 percent / CuSO₄

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen fluoride; hydrogen; nitric acid; sodium carbonate; sodium nitrite; platinum on activated charcoal; In various solvent(s); 1.1: Suzuki coupling / 4.1: Bamberger rearrangement;
DOI:10.2533/000942903777678650