(+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure

Base Information

Chemical Name:(+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure
CAS No.:500228-06-8
Molecular Formula:C₄₃H₄₈N₄O₁₀
Molecular Weight:780.875
Hs Code.:

(+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure

Synonyms:(+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure

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Chemical Property of (+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure

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Technology Process of (+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure

There total 5 articles about (+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 500228-05-7
(+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure-ethylester

: 500228-06-8
(+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 1h;
DOI:10.1002/hlca.200390015

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 500228-06-8
(+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / HOBT; DCC / CH₂Cl₂; ethyl acetate / 2 h / 20 °C

2: 100 percent / trifluoroacetic acid / toluene / 1 h / 20 °C

3: 88 percent / HOBT; DCC / ethyl acetate / 2 h / 20 °C

4: 91 percent / KOH / ethanol / 1 h / 20 °C

With potassium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1002/hlca.200390015

Reference yield:

: 89965-56-0
<3-<<4-(carboxyamino)butyl>amino>propyl>carbamic acid, dibenzyl ester

: 500228-06-8
(+)-(2S,3S)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2'-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / HOBT; DCC / CH₂Cl₂; ethyl acetate / 2 h / 20 °C

2: 100 percent / trifluoroacetic acid / toluene / 1 h / 20 °C

3: 88 percent / HOBT; DCC / ethyl acetate / 2 h / 20 °C

4: 91 percent / KOH / ethanol / 1 h / 20 °C

With potassium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1002/hlca.200390015