benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

Base Information

• Chemical Name: benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate
• CAS No.: 1308889-53-3
• Molecular Formula: C₂₄H₂₈N₂O₆
• Molecular Weight: 440.496
• Mol file: 1308889-53-3.mol

Synonyms:benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

Chemical Property of benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

There total 1 articles about benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-Dimethylamino-1-propanol (3179-63-3) + benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (1083312-78-0) → benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (1308889-53-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jm200148p

Reference yield:

benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (1308889-53-3) → 4-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate (1308889-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / tetrahydrofuran

2: pyridine; dichloromethane / 2 h / 20 °C

With palladium on carbon; hydrogen; In tetrahydrofuran; pyridine; dichloromethane;

DOI:10.1021/jm200148p

Reference yield:

benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (1308889-53-3) → N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide (1308889-57-7)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on carbon; hydrogen / tetrahydrofuran

2: pyridine; dichloromethane / 2 h / 20 °C

3: triethylamine / methanol / 20 °C

With palladium on carbon; hydrogen; triethylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane;

DOI:10.1021/jm200148p

upstream raw materials:

3-Dimethylamino-1-propanol

benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

Downstream raw materials:

4-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide