tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate

Base Information

• Chemical Name: tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate
• CAS No.: 1430751-38-4
• Molecular Formula: C₂₃H₃₀N₂O₄
• Molecular Weight: 398.502
• Mol file: 1430751-38-4.mol

Synonyms:tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate

Chemical Property of tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate

There total 3 articles about tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-phenyl-1,3-dioxolan-2-yl)acetaldehyde (125261-01-0) + tert-butyl 1-benzylhydrazine-1-carboxylate (147688-34-4) → tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate (1430751-38-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

ethyl 3,3-(ethylenedioxy)-3-phenylpropanoate (27773-03-1) → tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate (1430751-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / toluene / 0.17 h / -78 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In dichloromethane; toluene;

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate (1430751-38-4)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene / 15 h / Dean-Stark; Reflux

2: diisobutylaluminium hydride / toluene / 0.17 h / -78 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; In dichloromethane; toluene;

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

ethyl 3,3-(ethylenedioxy)-3-phenylpropanoate

2-(2-phenyl-1,3-dioxolan-2-yl)acetaldehyde

tert-butyl 1-benzylhydrazine-1-carboxylate

Downstream raw materials:

1-benzyl-4-iodo-5-phenyl-1H-pyrazole

1-benzyl-5-phenyl-1H-pyrazole

tert-butyl 1-benzyl-2-(3-oxo-3-phenylpropyl)hydrazinecarboxylate

6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-5-phenyl-1H-pyrazol-4-yl)pyridine-2-carboxylic acid