2-(benzyloxy)-5-(hydroxyethyl)-3-methoxybenzaldehyde trimethylene acetal

Base Information

Chemical Name:2-(benzyloxy)-5-(hydroxyethyl)-3-methoxybenzaldehyde trimethylene acetal
CAS No.:155351-70-5
Molecular Formula:C₂₀H₂₄O₅
Molecular Weight:344.408
Hs Code.:

Synonyms:2-(benzyloxy)-5-(hydroxyethyl)-3-methoxybenzaldehyde trimethylene acetal

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Chemical Property of 2-(benzyloxy)-5-(hydroxyethyl)-3-methoxybenzaldehyde trimethylene acetal

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Technology Process of 2-(benzyloxy)-5-(hydroxyethyl)-3-methoxybenzaldehyde trimethylene acetal

There total 4 articles about 2-(benzyloxy)-5-(hydroxyethyl)-3-methoxybenzaldehyde trimethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5034-74-2
5-bromo-3-methoxysalicylaldehyde

: 155351-70-5
2-(benzyloxy)-5-(hydroxyethyl)-3-methoxybenzaldehyde trimethylene acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 87.8 percent / K₂CO₃ / ethanol / 3 h / Heating

2: 99.7 percent / TsOH*H₂O / benzene / 1 h / Heating

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, Et₂O, from -78 deg C to 0 deg C, 2 h

With n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; In ethanol; benzene;
DOI:10.1021/ja00082a023

Reference yield:

: 100-39-0
benzyl bromide

: 155351-70-5
2-(benzyloxy)-5-(hydroxyethyl)-3-methoxybenzaldehyde trimethylene acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 87.8 percent / K₂CO₃ / ethanol / 3 h / Heating

2: 99.7 percent / TsOH*H₂O / benzene / 1 h / Heating

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, Et₂O, from -78 deg C to 0 deg C, 2 h

With n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; In ethanol; benzene;
DOI:10.1021/ja00082a023

Reference yield:

: 155351-68-1
2-O-benzyl-5-bromo-2-hydroxy-3-methoxybenzaldehyde

: 155351-70-5
2-(benzyloxy)-5-(hydroxyethyl)-3-methoxybenzaldehyde trimethylene acetal

Guidance literature:: Multi-step reaction with 2 steps

1: 99.7 percent / TsOH*H₂O / benzene / 1 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, Et₂O, from -78 deg C to 0 deg C, 2 h

With n-butyllithium; toluene-4-sulfonic acid; In benzene;
DOI:10.1021/ja00082a023