6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on

Base Information

Chemical Name:6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on
CAS No.:1256780-21-8
Molecular Formula:C₃₉H₅₄N₄O₃Si
Molecular Weight:654.968
Hs Code.:

Synonyms:6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on

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Chemical Property of 6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on

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Technology Process of 6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on

There total 4 articles about 6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.1%

: 1256779-87-9
methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate

: 42783-58-4
5-(benzyloxy)pyrimidin-2-amine

: 1256780-21-8
6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on

Guidance literature:: 5-(benzyloxy)pyrimidin-2-amine; With trimethylaluminum; In n-heptane; 1,2-dichloro-ethane; at 20 ℃; for 1h; Inert atmosphere;

methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate; In n-heptane; 1,2-dichloro-ethane; for 18h; Reflux;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256780-21-8
6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

4.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

4.2: 18 h / Reflux

With ammonium acetate; trimethylaluminum; phosphorus tribromide; sodium hydride; acetic acid; In n-heptane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1256779-86-8
methyl 2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-oxo heptanate

: 1256780-21-8
6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

1.2: 14 h / 70 °C

2.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

2.2: 18 h / Reflux

With ammonium acetate; trimethylaluminum; acetic acid; In n-heptane; 1,2-dichloro-ethane; toluene;