ethyl 3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylate

Base Information

Chemical Name:ethyl 3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylate
CAS No.:1616277-98-5
Molecular Formula:C₃₀H₃₁FN₄O₆S
Molecular Weight:594.664
Hs Code.:

Synonyms:ethyl 3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylate

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Chemical Property of ethyl 3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylate

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Technology Process of ethyl 3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylate

There total 14 articles about ethyl 3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332856-07-1
C₂₄H₁₉FN₂O₅S

: 21075-83-2
1-methyl-1-tert-butoxycarbonylhydrazine

: 1616277-98-5
ethyl 3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylate

Guidance literature:: C₂₄H₁₉FN₂O₅S; 1-methyl-1-tert-butoxycarbonylhydrazine; In ethanol; at 80 ℃; for 4h;

With hydrogenchloride; In ethanol; water; at 80 ℃; for 16h;

Reference yield:

: 1332855-99-8
C₈H₉FN₂S

: 1616277-98-5
ethyl 3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroform / 20 °C

2.1: hydrogenchloride / chloroform; tert-butyl methyl ether / 2 h / 20 °C

3.1: ethanol / 4 h / 80 °C

3.2: 16 h / 80 °C

With hydrogenchloride; In ethanol; tert-butyl methyl ether; chloroform;

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 1616277-98-5
ethyl 3-(benzyloxy)-1-((tert-butoxycarbonyl)(methyl)amino)-5-(5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-yl)-4-oxo-1,4-dihydropyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 60 °C

3.1: hydrogenchloride / methanol / 1 h / 20 °C

4.1: chloroform / 20 °C

5.1: hydrogenchloride / chloroform; tert-butyl methyl ether / 2 h / 20 °C

6.1: ethanol / 4 h / 80 °C

6.2: 16 h / 80 °C

With Lawessons reagent; hydrogenchloride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; tert-butyl methyl ether; chloroform;