(3S)-3-({2-amino-5-[4-(hydroxymethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

Base Information

Chemical Name:(3S)-3-({2-amino-5-[4-(hydroxymethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol
CAS No.:1376607-33-8
Molecular Formula:C₂₀H₃₀N₄O₃
Molecular Weight:374.483
Hs Code.:

Synonyms:(3S)-3-({2-amino-5-[4-(hydroxymethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

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Chemical Property of (3S)-3-({2-amino-5-[4-(hydroxymethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

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Technology Process of (3S)-3-({2-amino-5-[4-(hydroxymethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

There total 1 articles about (3S)-3-({2-amino-5-[4-(hydroxymethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376607-31-6
methyl 4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzoate

: 1376607-33-8
(3S)-3-({2-amino-5-[4-(hydroxymethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

Guidance literature:: methyl 4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzoate; With methanol; lithium borohydride; In tetrahydrofuran; at 60 ℃; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; for 0.333333h;

With sodium carbonate; In tetrahydrofuran; methanol; water;

Reference yield:

: 1376607-33-8
(3S)-3-({2-amino-5-[4-(hydroxymethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

: 1376514-17-8
4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzaldehyde

Guidance literature:: With manganese(IV) oxide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3.83333h;

Reference yield:

: 1376607-33-8
(3S)-3-({2-amino-5-[4-(hydroxymethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

: 1376607-09-8
(3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: manganese(IV) oxide / dichloromethane; tetrahydrofuran / 3.83 h / 20 °C

2.1: acetic acid / dichloromethane / 20 °C / Molecular sieve

2.2: 3 h / 0 °C

3.1: boron tribromide / dichloromethane / -70 - 20 °C

3.3: pH 7

With manganese(IV) oxide; boron tribromide; acetic acid; In tetrahydrofuran; dichloromethane;