2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol

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Chemical Name:2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol
CAS No.:1228103-47-6
Molecular Formula:C₂₆H₃₁N₃O₂SSi
Molecular Weight:477.703
Hs Code.:

Synonyms:2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol

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Chemical Property of 2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol

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Technology Process of 2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol

There total 6 articles about 2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1228102-93-9
methyl-2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)acetate

: 1228103-47-6
2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

: 41841-16-1
(4-bromo-phenyl)-acetic acid methyl ester

: 1228103-47-6
2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 85 °C

2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 80 °C

3: 1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 10 h / 20 °C

4: lithium aluminium tetrahydride / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; potassium acetate; sodium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki Coupling;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1228103-47-6
2-(4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide; dichloromethane / 10 h / 20 °C

2: lithium aluminium tetrahydride / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;