N₈-(3-(9H-purin-6-yl)pyridin-2-yl)-N₄-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine

Base Information

• Chemical Name: N₈-(3-(9H-purin-6-yl)pyridin-2-yl)-N₄-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine
• CAS No.: 1093100-61-8
• Molecular Formula: C₂₆H₁₉F₂N₉O
• Molecular Weight: 511.493

Synonyms:N₈-(3-(9H-purin-6-yl)pyridin-2-yl)-N₄-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine

Chemical Property of N₈-(3-(9H-purin-6-yl)pyridin-2-yl)-N₄-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₈-(3-(9H-purin-6-yl)pyridin-2-yl)-N₄-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine

There total 9 articles about N₈-(3-(9H-purin-6-yl)pyridin-2-yl)-N₄-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methyl-4-(methylthio)-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)quinazolin-8-amine (1093101-67-7) + 4-difluoromethoxyaniline (22236-10-8) → N8-(3-(9H-purin-6-yl)pyridin-2-yl)-N4-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine (1093100-61-8)

Guidance literature:

With trifluoroacetic acid; In 1,4-dioxane; at 160 ℃; for 0.2h; microwave;

Reference yield:

7-methyl-quinazolin-4(3H)-one (75844-40-5) → N8-(3-(9H-purin-6-yl)pyridin-2-yl)-N4-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine (1093100-61-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: methanol; acetic acid / 0.08 h / 20 °C

1.2: 3 h / 20 °C

2.1: sulfuric acid; nitric acid / 5.17 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h

4.1: Lawessons reagent; pyridine / 12 h / 100 °C

4.2: 0.5 h

5.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 6 h / 20 °C

6.1: trifluoroacetic acid / 1,4-dioxane / 0.2 h / 160 °C / microwave

With Lawessons reagent; pyridine; methanol; sulfuric acid; hydrogen; nitric acid; acetic acid; trifluoroacetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

6-bromo-7-methylquinazolin-4(3H)-one (943605-85-4) → N8-(3-(9H-purin-6-yl)pyridin-2-yl)-N4-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine (1093100-61-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 5.17 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h

3.1: Lawessons reagent; pyridine / 12 h / 100 °C

3.2: 0.5 h

4.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 6 h / 20 °C

5.1: trifluoroacetic acid / 1,4-dioxane / 0.2 h / 160 °C / microwave

With Lawessons reagent; pyridine; sulfuric acid; hydrogen; nitric acid; trifluoroacetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol;

upstream raw materials:

7-methyl-4-(methylthio)-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)quinazolin-8-amine

4-difluoromethoxyaniline

7-methyl-quinazolin-4(3H)-one

6-bromo-7-methylquinazolin-4(3H)-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1093100-61-8 N₈-(3-(9H-purin-6-yl)pyridin-2-yl)-N₄-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send