(2Z)-3-hydroxy-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-2-propen-1-one

Base Information

Chemical Name:(2Z)-3-hydroxy-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-2-propen-1-one
CAS No.:1453164-99-2
Molecular Formula:C₂₂H₂₂O₆
Molecular Weight:382.413
Hs Code.:

Synonyms:(2Z)-3-hydroxy-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-2-propen-1-one

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Chemical Property of (2Z)-3-hydroxy-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-2-propen-1-one

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Technology Process of (2Z)-3-hydroxy-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-2-propen-1-one

There total 3 articles about (2Z)-3-hydroxy-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 25983-76-0
isoevodionol

: 100-07-2
4-methoxy-benzoyl chloride

: 1453164-99-2
(2Z)-3-hydroxy-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-2-propen-1-one

Guidance literature:: isoevodionol; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -25 ℃; for 1h; Inert atmosphere;

4-methoxy-benzoyl chloride; In tetrahydrofuran; at -78 - 0 ℃; for 3.33333h; Inert atmosphere;
DOI:10.1002/hlca.201200278

Reference yield:

: 3602-54-8
4,6-dihydroxy-2-methoxyacetophenone

: 1453164-99-2
(2Z)-3-hydroxy-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-2-propen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: calcium hydroxide / methanol / 10 h / 20 °C / Reflux; Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -25 °C / Inert atmosphere

2.2: 3.33 h / -78 - 0 °C / Inert atmosphere

With calcium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.201200278

Reference yield:

: 107-86-8
3,3-dimethyl acrylaldehyde

: 1453164-99-2
(2Z)-3-hydroxy-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-2-propen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: calcium hydroxide / methanol / 10 h / 20 °C / Reflux; Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -25 °C / Inert atmosphere

2.2: 3.33 h / -78 - 0 °C / Inert atmosphere

With calcium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.201200278