6-(pyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]-2,2′-bipyridine

Base Information

• Chemical Name: 6-(pyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]-2,2′-bipyridine
• CAS No.: 914933-60-1
• Molecular Formula: C₂₂H₁₄F₃N₃
• Molecular Weight: 377.368
• Mol file: 914933-60-1.mol

Synonyms:6-(pyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]-2,2′-bipyridine

Chemical Property of 6-(pyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]-2,2′-bipyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(pyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]-2,2′-bipyridine

There total 1 articles about 6-(pyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]-2,2′-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-acetylpyridine (1122-62-9) + 4-Trifluoromethylbenzaldehyde (455-19-6) → 6-(pyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]-2,2′-bipyridine (914933-60-1)

Guidance literature:

With ammonium hydroxide; potassium hydroxide; In ethanol; for 144h; Reflux;

DOI:10.1021/acs.inorgchem.1c01233

Reference yield: 89.0%

rhenium(I) pentacarbonyl chloride (14099-01-5) + 6-(pyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]-2,2′-bipyridine (914933-60-1) → C25H14ClF3N3O3Re

Guidance literature:

In methanol; toluene; for 3h; Reflux; Inert atmosphere;

DOI:10.1021/acs.inorgchem.0c01939

Reference yield: 77.0%

di(rhodium)tetracarbonyl dichloride + 6-(pyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]-2,2′-bipyridine (914933-60-1) + silver trifluoromethanesulfonate (2923-28-6) → [Rh(4'-(4-(trifluoromethyl)phenyl)-2,2':6',2''-terpyridine)(CO)]OTf

Guidance literature:

di(rhodium)tetracarbonyl dichloride; silver trifluoromethanesulfonate; In tetrahydrofuran; at 20 ℃; for 0.25h;

4'-(4-(trifluoromethyl)phenyl)-2,2':6',2''-terpyridine; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jacs.8b04687

upstream raw materials:

2-acetylpyridine

4-Trifluoromethylbenzaldehyde