2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromene-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide

Base Information

• Chemical Name: 2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromene-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide
• CAS No.: 434333-11-6
• Molecular Formula: C₂₅H₁₅BrCl₂F₃NO₃
• Molecular Weight: 585.204

Synonyms:2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromene-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide

Chemical Property of 2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromene-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide

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Technology Process of 2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromene-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide

There total 1 articles about 2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromene-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromen-3-yl]acetic acid + 4-chloro-2-(trifluoromethyl)aniline (445-03-4) → 2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromene-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide (434333-11-6)

Guidance literature:

2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromen-3-yl]acetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1h;

4-chloro-2-(trifluoromethyl)aniline; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield: 63.0%

2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromene-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide (434333-11-6) + 4-phenyl-1-piperazine (92-54-6) → 2-[7-chloro-2-oxo-4-phenyl-6-[(4-phenylpiperazin-1-yl)methyl]-2H-chromen-3-yl]-N-[4-chloro-2-(trifluoromethyl)phenyl]acetamide (391686-69-4)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 0.5h;

Reference yield: 55.0%

sodium cyanide (773837-37-9) + 2-[6-(bromomethyl)-7-chloro-2-oxo-4-phenyl-2H-chromene-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide (434333-11-6) → 2-[7-chloro-6-(cyanomethyl)-2-oxo-4-phenyl-2H-chromen-3-yl]-N-(4-chloro-2-trifluoromethylphenyl)acetamide

Guidance literature:

In DMF (N,N-dimethyl-formamide); for 3h;

upstream raw materials:

4-chloro-2-(trifluoromethyl)aniline

Downstream raw materials:

2-[7-chloro-2-oxo-4-phenyl-6-[(4-phenylpiperazin-1-yl)methyl]-2H-chromen-3-yl]-N-[4-chloro-2-(trifluoromethyl)phenyl]acetamide

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