4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene

Base Information

Chemical Name:4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene
CAS No.:1416803-69-4
Molecular Formula:C₁₇H₁₈N₂O₃
Molecular Weight:298.342
Hs Code.:

Synonyms:4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene

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Chemical Property of 4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene

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Technology Process of 4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene

There total 4 articles about 4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 42867-34-5
1-((4-methylphenyl)methyl)-1H-pyrrole-2,5-dione

: 617-89-0
furan-2-ylmethanamine

: 1416803-69-4
4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene

Guidance literature:: 1-((4-methylphenyl)methyl)-1H-pyrrole-2,5-dione; With boric acid; at 90 ℃; for 0.333333h; Schlenk technique; Inert atmosphere;

furan-2-ylmethanamine; for 1h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c2ob26699g

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 1416803-69-4
4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

3.1: diethyl ether / 1 h / 20 °C

3.2: 6 h / 70 °C

4.1: boric acid / 0.33 h / 90 °C / Schlenk technique; Inert atmosphere

4.2: 1 h / Schlenk technique; Inert atmosphere

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; boric acid; sodium carbonate; In diethyl ether; ethanol;
DOI:10.1039/c2ob26699g

Reference yield:

: 104-84-7
para-methylbenzylamine

: 1416803-69-4
4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether / 1 h / 20 °C

1.2: 6 h / 70 °C

2.1: boric acid / 0.33 h / 90 °C / Schlenk technique; Inert atmosphere

2.2: 1 h / Schlenk technique; Inert atmosphere

With boric acid; In diethyl ether;
DOI:10.1039/c2ob26699g