2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole

Base Information

Chemical Name:2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole
CAS No.:1196103-64-6
Molecular Formula:C₁₈H₂₀FN₃O₃S₂
Molecular Weight:409.506
Hs Code.:

Synonyms:2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole

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Chemical Property of 2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole

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Technology Process of 2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole

There total 3 articles about 2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1196104-30-9
3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide

: 1196103-64-6
2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole

Guidance literature:: With Lawessons reagent; In toluene; at 110 ℃; for 2h;

Reference yield:

: 133674-39-2
3-tert-butylisoxazole-5-carboxylic acid methyl ester

: 1196103-64-6
2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium trimethylsilonate / tetrahydrofuran / 16 h / 20 °C

1.2: pH 1

2.1: pyridine; trichlorophosphate / 3 h / 0 °C / Inert atmosphere

3.1: Lawessons reagent / toluene / 2 h / 110 °C

With Lawessons reagent; pyridine; potassium trimethylsilonate; trichlorophosphate; In tetrahydrofuran; toluene;

Reference yield:

: 630-19-3
pivalaldehyde

: 1196103-64-6
2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / water; tert-butyl alcohol / 0.5 h / 20 °C

1.2: 2 h / Reflux

2.1: potassium trimethylsilonate / tetrahydrofuran / 16 h / 20 °C

2.2: pH 1

3.1: pyridine; trichlorophosphate / 3 h / 0 °C / Inert atmosphere

4.1: Lawessons reagent / toluene / 2 h / 110 °C

With Lawessons reagent; pyridine; hydroxylamine hydrochloride; potassium trimethylsilonate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water; toluene; tert-butyl alcohol;