3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide

Base Information

• Chemical Name: 3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide
• CAS No.: 1196104-30-9
• Molecular Formula: C₁₈H₂₂FN₃O₅S
• Molecular Weight: 411.454
• Mol file: 1196104-30-9.mol

Synonyms:3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide

Chemical Property of 3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide

There total 3 articles about 3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2-(4-fluoro-benzenesulfonyl)-2-methyl-propionic acid hydrazide (1196104-10-5) + 3-tert-butylisoxazole-5-carboxylic acid (133674-40-5) → 3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide (1196104-30-9)

Guidance literature:

With pyridine; trichlorophosphate; at 0 ℃;

Reference yield:

3-tert-butylisoxazole-5-carboxylic acid methyl ester (133674-39-2) → 3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide (1196104-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium trimethylsilonate / tetrahydrofuran / 16 h / 20 °C

1.2: pH 1

2.1: pyridine; trichlorophosphate / 3 h / 0 °C / Inert atmosphere

With pyridine; potassium trimethylsilonate; trichlorophosphate; In tetrahydrofuran;

Reference yield:

pivalaldehyde (630-19-3) → 3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide (1196104-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / water; tert-butyl alcohol / 0.5 h / 20 °C

1.2: 2 h / Reflux

2.1: potassium trimethylsilonate / tetrahydrofuran / 16 h / 20 °C

2.2: pH 1

3.1: pyridine; trichlorophosphate / 3 h / 0 °C / Inert atmosphere

With pyridine; hydroxylamine hydrochloride; potassium trimethylsilonate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water; tert-butyl alcohol;

upstream raw materials:

2-(4-fluoro-benzenesulfonyl)-2-methyl-propionic acid hydrazide

3-tert-butylisoxazole-5-carboxylic acid

pivalaldehyde

3-tert-butylisoxazole-5-carboxylic acid methyl ester

Downstream raw materials:

2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole