1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea

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Chemical Name:1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea
CAS No.:1610529-13-9
Molecular Formula:C₂₉H₂₇F₃N₆O₄
Molecular Weight:580.566
Hs Code.:

Synonyms:1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea

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Chemical Property of 1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea

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Technology Process of 1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea

There total 4 articles about 1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 8-trifluoromethyl-2-phenylimidazo[1,2-a]pyridin-3-amine dihydrochloride

: 1414575-99-7
phenyl (3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)carbamate

: 1610529-13-9
1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 20 ℃; for 16h;

Reference yield:

: 1414575-97-5
3-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-4-methyl-1-phenyl-1H-pyrazol-5-amine

: 1610529-13-9
1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethyl acetate; water / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 16 h / 20 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In N,N-dimethyl acetamide; water; ethyl acetate;

Reference yield:

: 934397-98-5
5-amino-4-methyl-1-phenyl-1H-pyrazol-3(2H)-one

: 1610529-13-9
1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

2: sodium hydroxide / ethyl acetate; water / 16 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 16 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In N,N-dimethyl acetamide; water; ethyl acetate; N,N-dimethyl-formamide;