4-amino-N-(1-benzyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-chloro-2-methoxybenzamide

Base Information

• Chemical Name: 4-amino-N-(1-benzyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-chloro-2-methoxybenzamide
• CAS No.: 172092-79-4
• Molecular Formula: C₂₁H₂₇ClN₄O₂
• Molecular Weight: 402.924

Synonyms:4-amino-N-(1-benzyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-chloro-2-methoxybenzamide

Chemical Property of 4-amino-N-(1-benzyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-chloro-2-methoxybenzamide

Chemical Property:

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Technology Process of 4-amino-N-(1-benzyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-chloro-2-methoxybenzamide

There total 2 articles about 4-amino-N-(1-benzyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-chloro-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

4-amino-5-chloro-2-methoxybenzoic acid (7206-70-4) + 6-amino-1-benzyl-4-methylhexahydro-1H-1,4-diazepine (129295-49-4) → 4-amino-N-(1-benzyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-chloro-2-methoxybenzamide (172092-79-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1248/cpb.43.1364

Reference yield:

N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)acetamide (129295-34-7) → 4-amino-N-(1-benzyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-chloro-2-methoxybenzamide (172092-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 10percent aq. HCl

2: 49 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 5 h / Ambient temperature

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1248/cpb.43.1364

Reference yield: 100.0%

4-amino-N-(1-benzyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-chloro-2-methoxybenzamide (172092-79-4) → 4-amino-5-chloro-2-methoxy-N-[1-methylhexahydro-1,4-diazepin-6-yl]benzamide

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃; for 3h;

DOI:10.1248/cpb.50.941

upstream raw materials:

4-amino-5-chloro-2-methoxybenzoic acid

6-amino-1-benzyl-4-methylhexahydro-1H-1,4-diazepine

N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)acetamide

Downstream raw materials:

4-amino-N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-5-chloro-2-hydroxybenzamide

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