diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

Base Information

Chemical Name:diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester
CAS No.:544686-86-4
Molecular Formula:C₄₀H₅₄NO₅PSi
Molecular Weight:687.932
Hs Code.:

diisopropyl-phosphoramidous acid benzyl ester 3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

Synonyms:diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

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Chemical Property of diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

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Technology Process of diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

There total 4 articles about diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 544686-85-3
2-O-(4-methoxybenzyl)-1-O-(tert-butyldiphenylsilyl)-sn-glycerol

: 108549-21-9
benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

: 544686-86-4
diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

Guidance literature:: With 1H-tetrazole; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.tetasy.2004.11.070

Reference yield:

: 544686-84-2
3-O-allyl-2-O-(4-methoxybenzyl)-1-O-(tert-butyldiphenylsilyl)-sn-glycerol

: 544686-86-4
diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DBU / (Ph₃P)3RhCl / ethanol / 0.25 h / 90 °C

2: 10.5 g / aqueous HCl / acetone / 0.17 h / 70 - 80 °C

3: 81 percent / tetrazole / CH₂Cl₂ / 0.5 h / 20 °C

With 1H-tetrazole; hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; Wilkinson's catalyst; In ethanol; dichloromethane; acetone;
DOI:10.1016/j.tetasy.2004.11.070

Reference yield:

: 544686-87-5
(S)-(-)-1-allyl-3-tert-butyldiphenylsilyl-sn-glycerol

: 544686-86-4
diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / sodium hydride / dimethylformamide / 1 h / 20 °C

2: DBU / (Ph₃P)3RhCl / ethanol / 0.25 h / 90 °C

3: 10.5 g / aqueous HCl / acetone / 0.17 h / 70 - 80 °C

4: 81 percent / tetrazole / CH₂Cl₂ / 0.5 h / 20 °C

With 1H-tetrazole; hydrogenchloride; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; Wilkinson's catalyst; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tetasy.2004.11.070