benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate

Base Information

Chemical Name:benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate
CAS No.:849240-69-3
Molecular Formula:C₅₁H₅₉O₉PSi
Molecular Weight:875.083
Hs Code.:

Synonyms:benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate

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Chemical Property of benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate

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Technology Process of benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate

There total 6 articles about benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Phosphorous acid benzyl ester (S)-2,3-bis-benzyloxy-propyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

: 849240-69-3
benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate

Guidance literature:: With tert.-butylhydroperoxide;
DOI:10.1002/anie.200390243

Reference yield:

: 544686-86-4
diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester

: 849240-69-3
benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole / CH₂Cl₂ / 1.5 h / 20 °C

2: 3.5 g / tert-butyl hydroperoxide / CH₂Cl₂; decane

With 1H-tetrazole; tert.-butylhydroperoxide; In decane; dichloromethane;
DOI:10.1016/j.tetasy.2004.11.070

Reference yield:

: 544686-84-2
3-O-allyl-2-O-(4-methoxybenzyl)-1-O-(tert-butyldiphenylsilyl)-sn-glycerol

: 849240-69-3
benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate

Guidance literature:: Multi-step reaction with 5 steps

1: DBU / (Ph₃P)3RhCl / ethanol / 0.25 h / 90 °C

2: 10.5 g / aqueous HCl / acetone / 0.17 h / 70 - 80 °C

3: 81 percent / tetrazole / CH₂Cl₂ / 0.5 h / 20 °C

4: tetrazole / CH₂Cl₂ / 1.5 h / 20 °C

5: 3.5 g / tert-butyl hydroperoxide / CH₂Cl₂; decane

With 1H-tetrazole; hydrogenchloride; tert.-butylhydroperoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; Wilkinson's catalyst; In decane; ethanol; dichloromethane; acetone;
DOI:10.1016/j.tetasy.2004.11.070