544686-84-2

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 544686-87-5 (S)-(-)-1-allyl-3-tert-butyldiphenylsilyl-sn-glycerol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 56083-15-9 (S)-4-((allyloxy)methyl)-2,2-dimethyl-1,3-dioxolane 
• 123-34-2 (R)-3-allyloxypropane-1,2-diol 

Downstream Products

• 849240-71-7 Phosphoric acid benzyl ester (S)-3-{benzyloxy-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propoxy]-phosphoryloxy}-2-(4-methoxy-benzyloxy)-propyl ester (S)-2,3-bis-benzyloxy-propyl ester 
• 849240-72-8 Phosphoric acid benzyl ester (R)-3-[benzyloxy-((S)-2,3-bis-benzyloxy-propoxy)-phosphoryloxy]-2-(4-methoxy-benzyloxy)-propyl ester (R)-3-hydroxy-2-(4-methoxy-benzyloxy)-propyl ester 
• 849240-69-3 benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-tert-butyldiphenylsilyloxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate 
• 849240-70-6 benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-hydroxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate 
• 544686-86-4 diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester 
• 544686-85-3 2-O-(4-methoxybenzyl)-1-O-(tert-butyldiphenylsilyl)-sn-glycerol 

Relevant academic research and scientific papers

Regioselective phosphorylation of: Myo -inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol

A regioselective phosphorylation method for myo-inositol was developed by utilizing readily preparable BINOL-derived phosphoramidites. The method also facilitated the complete separation of the diastereomeric products by simple chromatography. Based on this phosphorylation and Ni-catalyzed alkyl-alkyl cross-coupling reaction for long fatty acids, we achieved the first synthesis of a lysophosphatidylinositol, EhPIa having long fatty acid C30:1, as a partial structure of glycosylphosphatidylinositol (GPI) anchor from the cell membrane of a protozoa, Entamoeba histolytica.

Synthesis of structural variants of Staphylococcus aureus lipoteichoic acid (LTA)

Based on 1,2-O-isopropylidene-sn-glycerol, which is readily available from d-mannitol, five chiral building blocks for the construction of structural variants of Staphylococcus aureus LTA designed and synthesized. Ligation of these building blocks led readily to the target molecules 1 and 2. They demonstrated that the d-alanine residues at the glycerophosphate backbone are decisive for the activation of the immune system.