ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate

Base Information

Chemical Name:ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate
CAS No.:538336-04-8
Molecular Formula:C₂₈H₃₅N₅O₅
Molecular Weight:521.616
Hs Code.:

Synonyms:ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate

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Chemical Property of ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate

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Technology Process of ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate

There total 14 articles about ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 538336-04-8
ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate

Guidance literature:: Multi-step reaction with 6 steps

1: 44 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 °C

2: 92 percent / aq. NaOH / ethanol / 72 h

3: 71 percent / triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂

4: HCl / dioxane

5: ammonium carbonate / ethanol

6: triethylamine / ethanol

With ammonium carbonate; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1021/jm020485x

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 538336-04-8
ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate

Guidance literature:: Multi-step reaction with 6 steps

1: 44 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 °C

2: 92 percent / aq. NaOH / ethanol / 72 h

3: 71 percent / triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂

4: HCl / dioxane

5: ammonium carbonate / ethanol

6: triethylamine / ethanol

With ammonium carbonate; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1021/jm020485x

Reference yield:

: 162046-56-2
4-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid

: 538336-04-8
ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂

2: HCl / dioxane

3: ammonium carbonate / ethanol

4: triethylamine / ethanol

With ammonium carbonate; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm020485x