ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate

Base Information

Chemical Name:ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate
CAS No.:252261-63-5
Molecular Formula:C₂₈H₃₇N₅O₅
Molecular Weight:523.632
Hs Code.:

Synonyms:ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate

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Chemical Property of ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate

Chemical Property:

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Technology Process of ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate

There total 15 articles about ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 538336-04-8
ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate

: 252261-63-5
ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; atmospheric pressure;
DOI:10.1021/jm020485x

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 252261-63-5
ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate

Guidance literature:: Multi-step reaction with 7 steps

1: 44 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 °C

2: 92 percent / aq. NaOH / ethanol / 72 h

3: 71 percent / triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂

4: HCl / dioxane

5: ammonium carbonate / ethanol

6: triethylamine / ethanol

7: H₂ / Pd/C / methanol / atmospheric pressure

With ammonium carbonate; hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/jm020485x

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 252261-63-5
ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate

Guidance literature:: Multi-step reaction with 7 steps

1: 44 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 °C

2: 92 percent / aq. NaOH / ethanol / 72 h

3: 71 percent / triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂

4: HCl / dioxane

5: ammonium carbonate / ethanol

6: triethylamine / ethanol

7: H₂ / Pd/C / methanol / atmospheric pressure

With ammonium carbonate; hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/jm020485x