Chemical Property of Estradiol benzoate
Chemical Property:
- Vapor Pressure:4.08E-12mmHg at 25°C
- Melting Point:191-198 °C(lit.)
- Refractive Index:1.604
- Boiling Point:531.2 °C at 760 mmHg
- PKA:15.06±0.40(Predicted)
- Flash Point:212 °C
- PSA：46.53000
- Density:1.185 g/cm3
- LogP:5.12280
- Storage Temp.:2-8°C
- Solubility.:Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in methanol.
- Water Solubility.:0.4mg/L(25 oC)
- XLogP3:4.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:3
- Exact Mass:376.20384475
- Heavy Atom Count:28
- Complexity:582
- Purity/Quality:
-
99% *data from raw suppliers
Estradiol benzoate *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
60-61-40
- Safety Statements:
53-22-36/37/39-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)C5=CC=CC=C5
- Isomeric SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC(=O)C5=CC=CC=C5
-
Uses
antiacne, antineoplastic Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the tr
eatment of lesions produced by diminution of bodily production of estrogens. Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the treatment of lesions produced by diminution of bodily production of estrogens.
-
Clinical Use
Estradiol is a semisynthetic estrogen compound. Its effects will mimic that of estrogen in animals. The most common use in small animals has been to terminate pregnancy.
Estradiol benzoate also has been used to terminate pregnancy (5-10 mg/kg divided into two or three SQ injections). Estradiol cypionate formulation had high efficacy (95%), but it had serious adverse effects and is not recommended. Estradiol cypionate is longer acting and more potent than other estrogen formulations. Estradiol valerate injection (20 mg/mL) is also available for human medicine to treat hypoestrogenism.
