(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester
• CAS No.: 122752-67-4
• Molecular Formula: C₂₈H₄₈O₅
• Molecular Weight: 464.686

Synonyms:(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester

Chemical Property of (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester

There total 1 articles about (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cholic acid (81-25-4) + acetic anhydride (108-24-7) + trifluoroacetic anhydride (407-25-0) + tert-butyl alcohol (75-65-0) → (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester (122752-67-4) + t-butyl 3α-acetoxy-7α,12α-dihydroxy-5β-cholan-24-oate (130782-09-1) + 3α,7α-dihydroxy-12α-trifluoroacetoxy-5β-cholan-24-oic acid (130782-08-0) + tert-butyl 3α,7α-dihydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate (130781-88-3) + 3α-acetoxy-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oic acid (130782-04-6) + t-butyl 3α-acetoxy-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate (130782-07-9)

Guidance literature:

multistep reaction; new procedures for selective protected cholic acid derivatives;

Reference yield: 95.0%

(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester (122752-67-4) → cholic acid (81-25-4)

Guidance literature:

With potassium hydroxide; In methanol; water; for 0.0666667h; microwave irradiation;

DOI:10.1016/j.steroids.2004.09.007

Reference yield: 92.0%

(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester (122752-67-4) + 4-Nitrophenyl chloroformate (7693-46-1) → tert-butyl 3,7,12-tris((4-nitrophenoxycarbonyl)oxy)cholate

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201506781

upstream raw materials:

cholic acid

acetic anhydride

trifluoroacetic anhydride

tert-butyl alcohol

Downstream raw materials:

cholic acid

Taurocholic acid

N benzyl (3α,5β,7α,12α)3,7,12-trihydroxy-cholan-24-amide

glycocholic acid ethyl ester

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