N-(4-((2-(hydroxymethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-(4-((2-(hydroxymethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:1033132-80-7
Molecular Formula:C₁₈H₂₁F₃N₄O₄S
Molecular Weight:446.45
Hs Code.:

Synonyms:N-(4-((2-(hydroxymethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of N-(4-((2-(hydroxymethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of N-(4-((2-(hydroxymethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 5 articles about N-(4-((2-(hydroxymethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1033132-75-0
C₁₂H₁₈N₂O₃S

: 128694-63-3
1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid

: 1033132-80-7
N-(4-((2-(hydroxymethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm201699w

Reference yield:

: 129768-24-7
1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

: 1033132-75-0
C₁₂H₁₈N₂O₃S

: 1033132-80-7
N-(4-((2-(hydroxymethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With pyridine; In dichloromethane; for 2h;
DOI:10.1021/jm701239a

Reference yield:

: 349098-93-7
C₁₂H₁₆N₂O₅S

: 1033132-80-7
N-(4-((2-(hydroxymethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 4 h / 2585.81 Torr

2: pyridine / dichloromethane / 20 °C

With pyridine; palladium on activated charcoal; hydrogen; In methanol; dichloromethane;
DOI:10.1021/jm201699w