4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

Base Information

Chemical Name:4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide
CAS No.:406215-71-2
Molecular Formula:C₃₄H₄₆N₂O₆SSi
Molecular Weight:638.901
Hs Code.:

4-methyl-benzenesulfinic acid [1-{2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

Synonyms:4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

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Chemical Property of 4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

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Technology Process of 4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

There total 8 articles about 4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 58814-69-0
4,5-dimethoxy-2-methyl-benzonitrile

: (S)-(+)-2-[(2-tert-butyldimethylsiloxyethyl)-4,5-dimethoxybenzylidine]-p-toluenesulfinamide

: 4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

: 406215-71-2
4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

Guidance literature:: 4,5-dimethoxy-2-methyl-benzonitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

(S)-(+)-2-[(2-tert-butyldimethylsiloxyethyl)-4,5-dimethoxybenzylidine]-p-toluenesulfinamide; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1021/jo010988v

Reference yield:

: 494-99-5
1,2-dimethoxy-4-methylbenzene

: 406215-71-2
4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / N-bromosuccinimide / CHCl₃ / 4 h / Heating

2.1: 90 percent / dimethylformamide / 16 h / 120 °C

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 68 percent / tetrahydrofuran / 0.5 h / -78 °C

With N-Bromosuccinimide; lithium diisopropyl amide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo010988v

Reference yield:

: 52806-46-9
1-bromo-4,5-dimethoxy-2-methylbenzene

: 406215-71-2
4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / dimethylformamide / 16 h / 120 °C

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 68 percent / tetrahydrofuran / 0.5 h / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo010988v