1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione

Base Information

Chemical Name:1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione
CAS No.:120040-39-3
Molecular Formula:C₂₀H₂₈N₂O₇
Molecular Weight:408.452
Hs Code.:

Synonyms:1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione

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Chemical Property of 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione

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Technology Process of 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione

There total 6 articles about 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

: 108-23-6
isopropyl chloroformate

: 120040-38-2
1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

: 120040-39-3
1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1248/cpb.36.2607

Reference yield:

: 113296-74-5
(Z)-1-acetyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

: 120040-39-3
1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 12 h

2: 50.2 percent / hydrazine hydrate / dimethylformamide / 1 h / 25 °C

3: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 1 h

4: 69 percent / H₂SO₄ / trifluoroacetic acid / 12 h / 25 °C

5: 68.3 percent / hydrogen / 20percent palladium on carbon / ethanol / 4 h / 760 Torr

6: 81.4 percent / triethylamine, 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / 25 °C

With dmap; sulfuric acid; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1248/cpb.36.2607

Reference yield:

: 120063-29-8
(Z)-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

: 120040-39-3
1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 68.3 percent / hydrogen / 20percent palladium on carbon / ethanol / 4 h / 760 Torr

2: 81.4 percent / triethylamine, 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / 25 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1248/cpb.36.2607