diethyl 1-(2'-cyanobiphenyl-4-yl)methyl-2-propyl-1H-imidazole-4,5-dicarboxylate

Base Information

• Chemical Name: diethyl 1-(2'-cyanobiphenyl-4-yl)methyl-2-propyl-1H-imidazole-4,5-dicarboxylate
• CAS No.: 1199807-37-8
• Molecular Formula: C₂₆H₂₇N₃O₄
• Molecular Weight: 445.518
• Mol file: 1199807-37-8.mol

Synonyms:diethyl 1-(2'-cyanobiphenyl-4-yl)methyl-2-propyl-1H-imidazole-4,5-dicarboxylate

Chemical Property of diethyl 1-(2'-cyanobiphenyl-4-yl)methyl-2-propyl-1H-imidazole-4,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 1-(2'-cyanobiphenyl-4-yl)methyl-2-propyl-1H-imidazole-4,5-dicarboxylate

There total 1 articles about diethyl 1-(2'-cyanobiphenyl-4-yl)methyl-2-propyl-1H-imidazole-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile (114772-54-2) + diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate (144689-94-1) → diethyl 1-(2'-cyanobiphenyl-4-yl)methyl-2-propyl-1H-imidazole-4,5-dicarboxylate (1199807-37-8)

Guidance literature:

With potassium carbonate; In ISOPROPYLAMIDE; acetone; at 55 ℃; for 2h;

Reference yield:

diethyl 1-(2'-cyanobiphenyl-4-yl)methyl-2-propyl-1H-imidazole-4,5-dicarboxylate (1199807-37-8) + methylmagnesium chloride (676-58-4) → 1-[{2'-cyanobiphenyl-4-yl}methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazol-5-carboxylic acid ethyl ester (144690-96-0)

Guidance literature:

diethyl 1-(2'-cyanobiphenyl-4-yl)methyl-2-propyl-1H-imidazole-4,5-dicarboxylate; methylmagnesium chloride; In tetrahydrofuran; toluene; for 3.5h; Cooling with ice; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; toluene; pH=2.2;

upstream raw materials:

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate

Downstream raw materials:

1-[{2'-cyanobiphenyl-4-yl}methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazol-5-carboxylic acid ethyl ester