2,2,2-Trichloro-1-(2-chlorophenyl)ethanol

Base Information

• Chemical Name: 2,2,2-Trichloro-1-(2-chlorophenyl)ethanol
• CAS No.: 10291-39-1
• Molecular Formula: C8H6Cl4O
• Molecular Weight: 259.947
• Hs Code.: 2906299090
• Mol file: 10291-39-1.mol

Synonyms:Benzylalcohol, o-chloro-a-(trichloromethyl)- (6CI,7CI,8CI);1,1,1-Trichloro-2-(2-chlorophenyl)-2-hydroxyethane;2-Chloro-alpha-(trichloromethyl)benzenemethanol;NSC 5655;o-CTBA;o-Chloro-a-(trichloromethyl)benzyl alcohol;

Chemical Property of 2,2,2-Trichloro-1-(2-chlorophenyl)ethanol

Chemical Property:

• Vapor Pressure: 0.00015mmHg at 25°C
• Melting Point: 50 °C(Solv: ligroine (8032-32-4))
• Refractive Index: 1.596
• Boiling Point: 318.5 °C at 760 mmHg
• PKA: 11.55±0.20(Predicted)
• Flash Point: 146.4 °C
• PSA: 20.23000
• Density: 1.559 g/cm³
• LogP: 3.74360
• Solubility.: Acetone, DCM, Ethyl Acetate, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,1,1-Trichloro-2-(2-chlorophenyl)-2-hydroxyethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,1,1-Trichloro-2-(2-chlorophenyl)-2-hydroxyethane is an impurity in the synthesis of Dicofol (D436700), a chiral and may have enantiomer-specific activity.

Technology Process of 2,2,2-Trichloro-1-(2-chlorophenyl)ethanol

There total 3 articles about 2,2,2-Trichloro-1-(2-chlorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

chloroform (67-66-3,8013-54-5) + 2-chloro-benzaldehyde (89-98-5) → 2,2,2-trichloro-1-(2-chloro-phenyl)-ethanol (10291-39-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 4h;

DOI:10.1021/jo000584n

Reference yield:

2-chlorophenylmagnesium bromide (36692-27-0) + chloral (75-87-6) → 2,2,2-trichloro-1-(2-chloro-phenyl)-ethanol (10291-39-1)

Guidance literature:

With diethyl ether; at 0 ℃;

DOI:10.1021/ja01225a058

Reference yield:

→ 2,2,2-trichloro-1-(2-chloro-phenyl)-ethanol (10291-39-1)

Guidance literature:

aus o-Chlorbenzaldehyd und CHCl3 mit KOH in NH3(l.);

DOI:10.1007/BF00780152

upstream raw materials:

chloroform

2-chloro-benzaldehyde

2-chlorophenylmagnesium bromide

chloral

Downstream raw materials:

o,p'-DDT

1,1,1-trichloro-2,2-bis-(o-chlorophenyl)ethane

2,2‐dichloro‐1‐(2‐chlorophenyl)ethan‐1‐one

ethyl [2,2,2-trichloro-1-(2-chlorophenyl)ethyl]carbonate