t-butyl endo 4-(3-chloro-4-fluorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate

Base Information

Chemical Name:t-butyl endo 4-(3-chloro-4-fluorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate
CAS No.:716359-73-8
Molecular Formula:C₁₈H₂₂ClFN₂O₂
Molecular Weight:352.836
Hs Code.:

Synonyms:t-butyl endo 4-(3-chloro-4-fluorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate

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Chemical Property of t-butyl endo 4-(3-chloro-4-fluorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of t-butyl endo 4-(3-chloro-4-fluorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate

There total 4 articles about t-butyl endo 4-(3-chloro-4-fluorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 716359-71-6
[1-(t-butoxycarbonyl)-4-(3-chloro-4-fluorophenyl)piperidin-4-yl](cyano)acetic acid

: 716359-73-8
t-butyl endo 4-(3-chloro-4-fluorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate

Guidance literature:: With copper(I) oxide; In acetonitrile; for 0.5h; Inert atmosphere; Reflux;
DOI:10.1021/jm200279v

Reference yield:

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

: 716359-73-8
t-butyl endo 4-(3-chloro-4-fluorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / diethyl ether / 20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: water; sodium hydroxide / ethanol / 6.5 h / 20 °C

3.1: copper(I) oxide / acetonitrile / 0.5 h / Inert atmosphere; Reflux

With copper(I) oxide; water; magnesium; sodium hydroxide; In diethyl ether; ethanol; acetonitrile;
DOI:10.1021/jm200279v

Reference yield:

: 716359-69-2
t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

: 716359-73-8
t-butyl endo 4-(3-chloro-4-fluorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / ethanol / 6.5 h / 20 °C

2: copper(I) oxide / acetonitrile / 0.5 h / Inert atmosphere; Reflux

With copper(I) oxide; water; sodium hydroxide; In ethanol; acetonitrile;
DOI:10.1021/jm200279v