t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Base Information

Chemical Name:t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
CAS No.:716359-69-2
Molecular Formula:C₂₁H₂₆ClFN₂O₄
Molecular Weight:424.9
Hs Code.:

Synonyms:t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

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Chemical Property of t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

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Technology Process of t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

There total 3 articles about t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

: 60811-21-4
1-bromo-3-chloro-4-fluorobenzene

: 716359-69-2
t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: 1-bromo-3-chloro-4-fluorobenzene; With magnesium; In diethyl ether; at 20 ℃; Inert atmosphere;

tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate; With copper(l) iodide; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm200279v

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 716359-69-2
t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / benzene / 4 h / Dean Stark conditionsarkness; Reflux

2.1: magnesium / diethyl ether / 20 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

With ammonium acetate; magnesium; acetic acid; In diethyl ether; benzene;
DOI:10.1021/jm200279v

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 716359-69-2
t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / benzene / 4 h / Dean Stark conditionsarkness; Reflux

2.1: magnesium / diethyl ether / 20 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

With ammonium acetate; magnesium; acetic acid; In diethyl ether; benzene;
DOI:10.1021/jm200279v