1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal

Base Information

• Chemical Name: 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal
• CAS No.: 81111-93-5
• Molecular Formula: C₁₈H₂₂O₅S
• Molecular Weight: 350.436
• Mol file: 81111-93-5.mol

Synonyms:1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal

Chemical Property of 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal

There total 5 articles about 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-Hydroxypropiophenone dimethylacetal (73611-99-1) + p-toluenesulfonyl chloride (98-59-9) → 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal (81111-93-5)

Guidance literature:

In pyridine; Ambient temperature;

DOI:10.1016/S0040-4039(01)82941-5

Reference yield:

[hydroxy(tosyloxy)iodo]benzene (27126-76-7) → 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal (81111-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 6 h / Reflux

2.1: toluene-4-sulfonic acid / methanol / 3 h / Reflux

2.2: 48 h / Reflux

With toluene-4-sulfonic acid; In methanol; acetonitrile;

DOI:10.1021/acs.orglett.5b02966

Reference yield:

1-phenyl-propan-1-one (93-55-0) → 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal (81111-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 6 h / Reflux

2.1: toluene-4-sulfonic acid / methanol / 3 h / Reflux

2.2: 48 h / Reflux

With toluene-4-sulfonic acid; In methanol; acetonitrile;

DOI:10.1021/acs.orglett.5b02966

upstream raw materials:

2-Hydroxypropiophenone dimethylacetal

p-toluenesulfonyl chloride

2-bromo-1-phenyl-1-propanone

α-tosyloxypropiophenone

Downstream raw materials:

2-methoxy-1-phenyl-propan-1-one

2-phenylpropionic acid methyl ester