2-Hydroxypropiophenone dimethylacetal

Base Information

• Chemical Name: 2-Hydroxypropiophenone dimethylacetal
• CAS No.: 73611-99-1
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.246
• Mol file: 73611-99-1.mol

Synonyms:2-Hydroxypropiophenone dimethylacetal

Chemical Property of 2-Hydroxypropiophenone dimethylacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-Hydroxypropiophenone dimethylacetal

There total 5 articles about 2-Hydroxypropiophenone dimethylacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

sodium methylate (124-41-4) + 2-bromo-1-phenyl-1-propanone (2114-00-3) → 2-Hydroxypropiophenone dimethylacetal (73611-99-1)

Guidance literature:

In methanol;

DOI:10.1016/S0040-4039(01)82941-5

Reference yield: 84.0%

methanol (67-56-1) + Sulfuric acid 1-methyl-2-oxo-2-phenyl-ethyl ester 4-nitro-phenyl ester → 2-Hydroxypropiophenone dimethylacetal (73611-99-1)

Guidance literature:

With potassium carbonate; In methanol; for 0.25h; Ambient temperature;

DOI:10.1021/jo00352a002

Reference yield: 78.0%

methanol (67-56-1) + 1-phenyl-propan-1-one (93-55-0) → 2-Hydroxypropiophenone dimethylacetal (73611-99-1)

Guidance literature:

With sodium bromide; at 30 ℃; Product distribution; Mechanism; electrolysis (Pt-anode, Cu-Zn (60:40) cathode, 220 mA/cm² constant current); (electrochemically induced α-hydroxyketal);

DOI:10.1016/S0040-4020(01)87078-2

upstream raw materials:

2-methyl-1-methoxy-1-phenyl-oxirane

sodium methylate

methanol

2-bromo-1-phenyl-1-propanone

Downstream raw materials:

2-methoxy-1-phenyl-propan-1-one

1-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-1-phenyl-ethanol

2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-4-trimethylsilanyl-but-3-yn-2-ol

(S)-2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-but-3-yn-2-ol

Refernces

• 1、 Nikishin, Gennady I.,Elinson, Michail N.,Makhova, Irina V.. "Electrochemical oxidation of ketones in methanol in the presence of alkali metal bromides". . p. 895 - 905. Retrieved 2007/10/02.
• 2、 Hoffman, Robert V.,Jankowski, Bryan C.,Carr, C. Sean,Duesler, Eileen N.. "The Reactions of α-Arylsulfonoxy Ketones with Nucleophiles". . p. 130 - 135. Retrieved 2007/10/02.