6-{3-[(dimethylamino)methyl]-4-fluorophenyl}-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylic acid methyl ester

Base Information

Chemical Name:6-{3-[(dimethylamino)methyl]-4-fluorophenyl}-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylic acid methyl ester
CAS No.:1365986-83-9
Molecular Formula:C₂₃H₂₇FN₂O₂
Molecular Weight:382.478
Hs Code.:

Synonyms:6-{3-[(dimethylamino)methyl]-4-fluorophenyl}-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylic acid methyl ester

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Chemical Property of 6-{3-[(dimethylamino)methyl]-4-fluorophenyl}-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylic acid methyl ester

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Technology Process of 6-{3-[(dimethylamino)methyl]-4-fluorophenyl}-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylic acid methyl ester

There total 8 articles about 6-{3-[(dimethylamino)methyl]-4-fluorophenyl}-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1346575-80-1
methyl 6-(4-fluoro-3-formylphenyl)-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylate

: 124-40-3
dimethyl amine

: 1365986-83-9
6-{3-[(dimethylamino)methyl]-4-fluorophenyl}-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: methyl 6-(4-fluoro-3-formylphenyl)-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylate; dimethyl amine; With acetic acid; In tetrahydrofuran; dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 1346575-78-7
methyl 6-bromo-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylate

: 1365986-83-9
6-{3-[(dimethylamino)methyl]-4-fluorophenyl}-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 110 °C / Inert atmosphere

2.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With potassium phosphate; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1.1: Suzuki Coupling;

Reference yield:

: 374538-01-9
(4-fluoro-3-formylphenyl)boronic acid

: 1365986-83-9
6-{3-[(dimethylamino)methyl]-4-fluorophenyl}-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 110 °C / Inert atmosphere

2.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With potassium phosphate; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1.1: Suzuki Coupling;