3-(Acetylamino)-2-naphthoic acid

Base Information

• Chemical Name: 3-(Acetylamino)-2-naphthoic acid
• CAS No.: 19717-59-0
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.235
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID40427939
• Wikidata: Q82240690
• Mol file: 19717-59-0.mol

Synonyms:19717-59-0;3-(acetylamino)-2-naphthoic acid;3-Acetamido-2-naphthoic acid;3-acetamidonaphthalene-2-carboxylic Acid;3-Acetamido-2-naphthoicacid;SCHEMBL5860670;DTXSID40427939;HMS1733K12;AKOS000264233;SB76965;3-(ACETYLAMINO)-2-NAPHTHOICACID;BS-21901;EN300-18571;Z85894475

Chemical Property of 3-(Acetylamino)-2-naphthoic acid

Chemical Property:

• Vapor Pressure: 4.15E-10mmHg at 25°C
• Boiling Point: 482.2°Cat760mmHg
• PKA: 3.63±0.30(Predicted)
• Flash Point: 245.4°C
• PSA: 69.89000
• Density: g/cm³
• LogP: 3.14590
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 229.07389321
• Heavy Atom Count: 17
• Complexity: 316

Purity/Quality:

99% ^*data from raw suppliers

3-Acetamidonaphthoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC2=CC=CC=C2C=C1C(=O)O

Technology Process of 3-(Acetylamino)-2-naphthoic acid

There total 5 articles about 3-(Acetylamino)-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetyl chloride (75-36-5) + 2-Amino-3-naphthoic acid (5959-52-4) → 3-acetamido-2-naphthoic acid (19717-59-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1080/00397911.2017.1328514

Reference yield:

acetic anhydride (108-24-7) + 2-Amino-3-naphthoic acid (5959-52-4) → 3-acetamido-2-naphthoic acid (19717-59-0)

Guidance literature:

With sodium hydroxide; at 40 ℃;

DOI:10.1039/jr9500000961

Reference yield:

2-aminonaphthalene-1-carboxylic acid (79979-69-4) + acetic anhydride (108-24-7) → 3-acetamido-2-naphthoic acid (19717-59-0)

Guidance literature:

at 140 ℃; for 3h;

DOI:10.1021/ml500497s

upstream raw materials:

acetic anhydride

2-Amino-3-naphthoic acid

2-methyl-4H-naphth<2,3-d><1,3>oxazin-4-one

acetic acid

Downstream raw materials:

2-methylbenzo[g]quinazolin-4(3H)-one