26-benzyloxy-25R-Δ₂₂-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol

Base Information

Chemical Name:26-benzyloxy-25R-Δ₂₂-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol
CAS No.:126559-93-1
Molecular Formula:C₅₁H₇₄O₁₅
Molecular Weight:927.14
Hs Code.:

26-benzyloxy-25R-Δ<sub>22</sub>-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol

Synonyms:26-benzyloxy-25R-Δ₂₂-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol

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Chemical Property of 26-benzyloxy-25R-Δ₂₂-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol

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Technology Process of 26-benzyloxy-25R-Δ₂₂-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol

There total 14 articles about 26-benzyloxy-25R-Δ₂₂-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72297-80-4
1-[((S)-3-iodo-2-methylpropoxy)methyl]benzene

: 126559-93-1
26-benzyloxy-25R-Δ₂₂-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / toluene / 18 h / Heating

2: n-BuLi / tetrahydrofuran / 0.33 h / -10 °C

3: 50 percent / tetrahydrofuran / 1 h / -20 - 0 °C

4: 3.0 g / NaOH / tetrahydrofuran; methanol; H₂O / 6.5 h / Heating

5: 91 percent / pyridine / dioxane / cooling then rt., 30 min

6: 1.) Me₃SiOTf, molecular sieves 4 Angstroem / 1.) C₂H₄Cl₂, -20 deg C, 1 h 2.) C₂H₄Cl₂, -20 deg C, 14 h

With pyridine; sodium hydroxide; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;
DOI:10.1016/S0040-4020(01)89488-6

Reference yield:

: 63930-49-4
(R)-3-(benzyloxy)-2-methylpropan-1-ol

: 126559-93-1
26-benzyloxy-25R-Δ₂₂-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / triphenylphosphine, N-iodosuccinimide / CH₂Cl₂ / 0.33 h / 0 °C

2: 85 percent / toluene / 18 h / Heating

3: n-BuLi / tetrahydrofuran / 0.33 h / -10 °C

4: 50 percent / tetrahydrofuran / 1 h / -20 - 0 °C

5: 3.0 g / NaOH / tetrahydrofuran; methanol; H₂O / 6.5 h / Heating

6: 91 percent / pyridine / dioxane / cooling then rt., 30 min

7: 1.) Me₃SiOTf, molecular sieves 4 Angstroem / 1.) C₂H₄Cl₂, -20 deg C, 1 h 2.) C₂H₄Cl₂, -20 deg C, 14 h

With pyridine; sodium hydroxide; N-iodo-succinimide; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(01)89488-6

Reference yield:

: 81-25-4
cholic acid

: 126559-93-1
26-benzyloxy-25R-Δ₂₂-3α-cathyl-7α-β-galactoperacetyl-5β-cholestane-12α-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 94.7 percent / 4-dimethylaminopyridine / pyridine / 3.5 h / 0 deg C then rt., 3.5 h

2: 48 percent / iodosobenzene diacetate, iodine / CCl₄ / 2 h / Heating; Irradiation

3: 89 percent / silver carbonate / acetone; H₂O / 1.) 2.5 h 2.) reflux, overnight

4: 85 percent / PCC / CH₂Cl₂ / 1.5 h

5: 50 percent / tetrahydrofuran / 1 h / -20 - 0 °C

6: 3.0 g / NaOH / tetrahydrofuran; methanol; H₂O / 6.5 h / Heating

7: 91 percent / pyridine / dioxane / cooling then rt., 30 min

8: 1.) Me₃SiOTf, molecular sieves 4 Angstroem / 1.) C₂H₄Cl₂, -20 deg C, 1 h 2.) C₂H₄Cl₂, -20 deg C, 14 h

With pyridine; dmap; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; [bis(acetoxy)iodo]benzene; 4 A molecular sieve; iodine; silver carbonate; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; tetrachloromethane; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(01)89488-6