N^α-benzyloxycarbonyl-N^G-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine

Base Information

• Chemical Name: N^α-benzyloxycarbonyl-N^G-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine
• CAS No.: 75813-41-1
• Molecular Formula: C₂₃H₃₀N₄O₇S
• Molecular Weight: 506.58
• Mol file: 75813-41-1.mol

Synonyms:N^α-benzyloxycarbonyl-N^G-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine

Chemical Property of N^α-benzyloxycarbonyl-N^G-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-benzyloxycarbonyl-N^G-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine

There total 2 articles about N^α-benzyloxycarbonyl-N^G-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Arg-OH (1234-35-1) + 4-methoxy-2,6-dimethylbenzenesulfonyl chloride (55661-08-0) → Nα-benzyloxycarbonyl-NG-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine (75813-41-1)

Guidance literature:

With sodium hydroxide; In acetone; for 3h; Yield given; Ambient temperature; addition at 5 deg C;

DOI:10.1248/cpb.29.2592

Reference yield:

3,5-dimethylmethoxybenzene (874-63-5) + Z-Arg-OH (1234-35-1) → Nα-benzyloxycarbonyl-NG-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine (75813-41-1) + Nα-benzyloxycarbonyl-NG-(2-methoxy-4,6-dimethylbenzenesulphonyl)arginine + C23H29ClN4O7S

Guidance literature:

With chlorosulfonic acid; Product distribution;

DOI:10.1039/c39810001243

Reference yield:

Nα-benzyloxycarbonyl-NG-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine (75813-41-1) → L-arginine (74-79-3,25212-18-4)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd black

3: TFA, 5percent thioanisole / 50 °C

With methyl-phenyl-thioether; hydrogen; trifluoroacetic acid; palladium;

DOI:10.1039/c39800000668

upstream raw materials:

3,5-dimethylmethoxybenzene

Z-Arg-OH

4-methoxy-2,6-dimethylbenzenesulfonyl chloride

Downstream raw materials:

C₃₀H₄₂N₆O₇S

N^G-Mds-Arg

L-arginine

Boc-Arg(Mds)-OH