(R)-(+)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane

Base Information

• Chemical Name: (R)-(+)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane
• CAS No.: 502763-41-9
• Molecular Formula: C₁₆H₂₂S
• Molecular Weight: 246.417
• Mol file: 502763-41-9.mol

Synonyms:(R)-(+)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane

Chemical Property of (R)-(+)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(+)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane

There total 6 articles about (R)-(+)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

diphenyldisulfane (882-33-7) + ((R)-(-)-2,2-dimethyl-6-methylene-1-cyclohexyl)methanol (166022-33-9) → (R)-(+)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane (502763-41-9)

Guidance literature:

With pyridine; tributylphosphine; at 20 ℃; for 15h;

DOI:10.1016/S0040-4020(02)01455-2

Reference yield:

C17H24O3S + thiophenol (108-98-5) → (R)-(+)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane (502763-41-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 12h;

DOI:10.3390/md17040245

Reference yield:

(R)-(2,2-dimethyl-6-methylenecyclohexyl)methyl acetate (930649-64-2) → (R)-(+)-2,2-dimethyl-6-methylene-1-[1'-(phenylthio)methyl]cyclohexane (502763-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / Reflux

2: potassium carbonate / dimethyl sulfoxide / 12 h / 20 °C

With potassium carbonate; sodium hydroxide; In methanol; dimethyl sulfoxide;

DOI:10.3390/md17040245

upstream raw materials:

diphenyldisulfane

((R)-(-)-2,2-dimethyl-6-methylene-1-cyclohexyl)methanol

thiophenol

(R)-(2,2-dimethyl-6-methylenecyclohexyl)methyl acetate

Downstream raw materials:

(R)-(-)-1-[1'-(benzenesulfonyl)methyl]-2,2-dimethyl-6-methylenecyclohexane

(2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene

(R)-(-)-(2E,6E)-9-(2,2-dimethyl-6-methylenencyclohexyl)-3,7-dimethyl-2,6-nonadien-1-ol