2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline

Base Information

Chemical Name:2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline
CAS No.:1427407-33-7
Molecular Formula:C₂₀H₁₅Cl₂F₂NO
Molecular Weight:394.248
Hs Code.:

Synonyms:2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline

Chemical Property:

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Technology Process of 2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline

There total 8 articles about 2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1427407-32-6
N-(2,6-dichloro-3-methoxy-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide

: 1427407-33-7
2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline

Guidance literature:: With borane-THF; In tetrahydrofuran; at 60 ℃;

Reference yield:

: 1214382-15-6
C₁₃H₇ClF₂O

: 1427407-33-7
2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

2: borane-THF / tetrahydrofuran / 60 °C

With borane-THF; sodium hydride; In tetrahydrofuran;

Reference yield:

: 38902-87-3
3-nitro-2,4-dichlorophenol

: 1427407-33-7
2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

3.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 60 °C

With borane-THF; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; ethyl acetate; acetone;