2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Base Information

Chemical Name:2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide
CAS No.:1312304-17-8
Molecular Formula:C₂₁H₂₅N₃O₃
Molecular Weight:367.448
Hs Code.:

Synonyms:2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide

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Chemical Property of 2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Chemical Property:

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Technology Process of 2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide

There total 9 articles about 2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312304-16-7
tert-butyl 3-(5-(3,4-dimethoxyphenylcarbamoyl)-1H-indol-2-yl)propyl(methyl)carbamate

: 1312304-17-8
2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; for 2.5h;

Reference yield:

: 15252-44-5
1-amino-pent-4-yne

: 1312304-17-8
2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 20 °C / Ice/water bath

2.1: sodium hydride / tetrahydrofuran / 20 °C / Ice/water bath

2.2: 72 h

3.1: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

4.1: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

5.1: hydrogenchloride / dichloromethane; diethyl ether / 2.5 h

With hydrogenchloride; sodium hydride; diethylamine; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 2122-63-6
4-amino-3-iodobenzoic acid

: 1312304-17-8
2-(3-methylamino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 24 h / 20 °C

2: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

3: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

4: hydrogenchloride / dichloromethane; diethyl ether / 2.5 h

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;