(+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile

Base Information

• Chemical Name: (+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile
• CAS No.: 116078-62-7
• Molecular Formula: C₂₇H₃₆ClN₃
• Molecular Weight: 438.056
• Mol file: 116078-62-7.mol

Synonyms:(+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile

Chemical Property of (+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile

There total 4 articles about (+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-chloroethyl)-N-(1-methylethyl)benzenemethanamine, monohydrochloride (66903-14-8) + (±)-α-(2-chlorophenyl)-1-piperidinebutanenitrile (116078-61-6) → (+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile (116078-62-7)

Guidance literature:

With potassium hydroxide; In n-heptane; water; dimethyl sulfoxide;

Reference yield:

SKF 353 (40737-53-9) + (±)-α-(2-chlorophenyl)-1-piperidinebutanenitrile (116078-61-6) → (+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile (116078-62-7)

Guidance literature:

With sodium amide; In toluene; at 90 ℃; for 2h;

DOI:10.1021/jm00119a017

Reference yield:

2-(piperidin-4-yl)ethyl chloride (1932-03-2) → (+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile (116078-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 38 percent / sodamide / toluene / 1.5 h / 80 °C

2: NaNH₂ / toluene / 2 h / 90 °C

With sodium amide; In toluene;

DOI:10.1021/jm00119a017

upstream raw materials:

SKF 353

(±)-α-(2-chlorophenyl)-1-piperidinebutanenitrile

2-(piperidin-4-yl)ethyl chloride

2-Chlorophenylacetonitrile

Downstream raw materials:

(+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanamide

(+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide

(+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile

Bidisomide

Refernces

• 1、 Desai,Fowler,Chorvat,Frederick,Hatley,Rorig,Garthwaite. "Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: Monobasic derivatives of disobutamide". . p. 2158 - 2164. Retrieved 2007/10/02.